Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging.
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What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions - they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.

To counter this decline, we can activate the body's own defenses against aging by stressing the body. Eat less, eat less protein, engage in intense exercise, experience uncomfortable cold. When the body senses existential threats it triggers longevity genes, which attempt to maintain the body to ensure its survival until good times return. This may be the evolutionary legacy of early bacteria, which established these two modes of living (repair and protect vs grow and reproduce). Scientists are uncovering ways to mimic stresses on the body without the discomfort of fasting. Molecules like NMN also trigger sirtuins to monitor and repair the epigenome. This may slow aging.

Reversing aging requires an epigenetic reset, which may be possible using Yamanaka factors. These four factors can revert an adult cell into a pluripotent stem cell. Prof. Sinclair used three of the four factors to reverse aging in the retinal cells of old mice. He found they could see again after the treatment.

Special thanks to:
Professor David Sinclair, check out his book "Lifespan: Why We Age & Why We Don't Have To"
Assistant Professor David Gold
Noemie Sierra (for polyp images)
Genepool Productions for telomere animations from Immortal: https://ve42.co/immortal
Epigenetics animations (DNA, histones, methylation etc) courtesy of: http://wehi.tv
Animation: Etsuko Uno
Art and Technical Direction: Drew Berry
Sound Design: Francois Tetaz & Emma Bortignon
Scientific Consultation: Marnie Blewitt
Courtesy of Walter and Eliza Hall Institute of Medical Research

Filming, editing and animation by Jonny Hyman and Derek Muller

Music from https://epidemicsound.com "Clearer Views" "Innovations" "A Sound Foundation" "Seaweed"
Additional music by Kevin MacLeod from https://incompetech.com "Marty Gots a Plan"

Bill Gross has founded a lot of start-ups, and incubated many others — and he got curious about why some succeeded and others failed. So he gathered data from hundreds of companies, his own and other people's, and ranked each company on five key factors. He found one factor that stands out from the others — and surprised even him.

TEDTalks is a daily video podcast of the best talks and performances from the TED Conference, where the world's leading thinkers and doers give the talk of their lives in 18 minutes (or less). Look for talks on Technology, Entertainment and Design -- plus science, business, global issues, the arts and much more.
Find closed captions and translated subtitles in many languages at http://www.ted.com/talks/bill_....gross_the_single_big

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Creamy Tuscan Chicken in a light and satisfying parmesan sun-dried tomato cream sauce.
⬇️⬇️⬇️⬇️ RECIPE BELOW ⬇️⬇️⬇️⬇️

TUSCAN CHICKEN INGREDIENTS:
►2 large chicken breasts, halved (1 1/2 lbs)
►1 tsp salt, divided, or to taste
►1/2 tsp black pepper, divided
►1/2 tsp garlic powder
►2 Tbsp olive oil, divided
►1 Tbsp butter
►8 oz mushrooms, thickly sliced
►1/4 cup sun-dried tomatoes (packed), drained and chopped
►1/4 cup green onion, green parts, chopped
►3 garlic cloves, minced
►1 1/2 cups heavy whipping cream
►1/2 cup parmesan cheese, shredded
►2 cups fresh spinach

🖨 PRINT RECIPE HERE: coming soon

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A simple, elegant Pan Seared Salmon recipe in a lemon browned butter sauce. Master this easy (10-minute) method for how to cook salmon in a pan. You won’t believe the easy ingredients!
­⬇️⬇️⬇️⬇️ RECIPE BELOW ⬇️⬇️⬇️⬇️

🐟 INGREDIENTS FOR PAN-SEARED SALMON:
►1 1/4 lb skinless boneless salmon filets cut into 4 filets (5 oz each about 1" thick)
►1/2 tsp salt
►1/8 tsp black pepper
►4 Tbsp unsalted butter
►1 tsp grated lemon zest
►4 Tbsp freshly squeezed lemon juice from 2 lemons
►1 Tbsp fresh parsley, minced

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🍽 MORE SALMON RECIPES:
►Healthy Cobb Seafood Salmon Salad with Easy Salad Dressing - https://youtu.be/Z5oocJROdsk
►Apricot Dijon Glazed Salmon and Broccoli (One Pan Meal) - https://youtu.be/vvgGk9t54XA
►Avocado Salmon Salad Recipe - https://youtu.be/vbV1h68Mnms
►Smoked Salmon Salad Recipe - Russian Shuba with a Twist - https://youtu.be/WPPARIBNRU8
►How To Make Salmon Cakes Recipe - Quick and Easy Salmon Patties -https://youtu.be/gOwBlnSmuxw
►Easy One-Pan Salmon and Asparagus Recipe - https://youtu.be/Kdq3khk_8n0
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🔍 In this video, we unravel the layers of AI, Machine Learning, Deep Learning, and their applications in tools like #chatgpt and Google #bard we first go through how AI is a broad field of study that encompasses #machinelearning as a sub-field.

We then break down Machine Learning into supervised and unsupervised models, using real-world examples to illustrate their functions and differences.

We move deeper into Deep Learning: Learn about artificial neural networks and the power of semi-supervised learning in applications like fraud detection in banking.

Then we delve into Generative AI, differentiating it from discriminative models and demonstrating its capabilities in creating new, innovative outputs.

Finally we walk through Large Language Models (LLMs) and uncover the significance of LLMs in AI, their pre-training processes, and their customization for specific industry applications

*THE NO BS PRODUCTIVITY NEWSLETTER* 📧
https://www.jeffsu.org/productivity-ping/

*TIMESTAMPS*
00:00 Google’s AI Course in 10 Minutes
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05:15 What is Generative AI?
07:05 What are Large Language Models?

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Michio Kaku: The Universe in a Nutshell
Watch the newest video from Big Think: https://bigth.ink/NewVideo
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OVERVIEW:

In a profoundly informative and deeply optimistic discussion, Professor Michio Kaku delivers a glimpse of where science will take us in the next hundred years, as warp drives, teleportation, inter-dimensional wormholes, and even time travel converge with our scientific understanding of physical reality. While firing up our imaginations about the future, he also presents a succinct history of physics to the present.
----------------------------------------------------------------------------------
MICHIO KAKU:

Dr. Michio Kaku is the co-founder of string field theory, and is one of the most widely recognized scientists in the world today. He has written 4 New York Times Best Sellers, is the science correspondent for CBS This Morning and has hosted numerous science specials for BBC-TV, the Discovery/Science Channel. His radio show broadcasts to 100 radio stations every week. Dr. Kaku holds the Henry Semat Chair and Professorship in theoretical physics at the City College of New York (CUNY), where he has taught for over 25 years. He has also been a visiting professor at the Institute for Advanced Study as well as New York University (NYU).
----------------------------------------------------------------------------------
TRANSCRIPT:

My name is Professor Michio Kaku. I’m a professor of theoretical physics at the City University of New York and I specialize in something called string theory. I’m a physicist.
Some people ask me the question, “What has physics done for me lately? I mean, do I get better color television, do I get better internet reception with physics?” And the answer is yes. You see, physics is at the very foundation of matter and energy. We physicists invented the laser beam, we invented the transistor. We helped to create the first computer. We helped to construct the internet. We wrote the World Wide Web. In addition, we also helped to invent television, radio, radar, microwaves, not to mention MRI scans, PET scans, x-rays. In other words, almost everything you see in your living room, almost everything you see in a modern hospital, at some point or other, can be traced to a physicist.

Now, I got interested in physics when I was a child. When I was a child of eight, something happened to me that changed my life and I wanted to be part of this grand search for a theory of everything. When I was eight, a great scientist had just died. I still remember my elementary school teacher coming into the...

To read the full transcript and for more info, please visit https://bigthink.com/videos/un....iverse-in-a-nutshell
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Big Think is the leading source of expert-driven, actionable, educational content -- with thousands of videos, featuring experts ranging from Bill Clinton to Bill Nye, we help you get smarter, faster. S​ubscribe to learn from top minds like these daily. Get actionable lessons from the world’s greatest thinkers & doers. Our experts are either disrupting or leading their respective fields. ​We aim to help you explore the big ideas and core skills that define knowledge in the 21st century, so you can apply them to the questions and challenges in your own life.

Other Frequent contributors include Michio Kaku & Neil DeGrasse Tyson.

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Body language, both the speaker's and the audience's, is a powerful form of communication that is difficult to master, especially if the speaker is nervous. This video will teach you how to use your body language effectively, read the audience's body language and what to do when they look bored or disconnected. Use these tools to enhance your nonverbal communication abilities and better connect with your audiences.
Presented by Stanford graduate students Matt Levy, Colin Bailie, Jeong Joon Ha, and Jennifer Rosenfeld. Created as an exemplary final project in Lecturer JD Schramm's Strategic Communication course. Learn more about communication techniques and best practices on "Think Fast, Talk Smart: The Podcast." https://www.gsb.stanford.edu/i....nsights/think-fast-t

Learn Python basics in 1 hour! ⚡ This beginner-friendly tutorial will get you coding fast.

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📖 TABLE OF CONTENT
0:00:00 Introduction
0:00:30 What You Can Do With Python
0:01:15 Your First Python Program
0:05:30 Variables
0:09:08 Receiving Input
0:10:48 Type Conversion
0:18:49 Strings
0:23:41 Arithmetic Operators
0:25:59 Operator Precedence
0:27:11 Comparison Operators
0:28:52 Logical Operators
0:31:06 If Statements
0:36:16 Exercise
0:41:42 While Loops
0:45:11 Lists
0:48:47 List Methods
0:52:16 For Loops
0:54:54 The range() Function
0:57:43 Tuples

#python #ai #machinelearning #webdevelopment

Today on Behind The Brand, Seth Godin details everything you (probably) don't know about marketing. Marketing is often a misunderstood concept often viewed as simply creating demand and driving brand awareness. Seth Godin dispels this view by explaining the difference between brand marketing and direct marketing, evaluating the value of a brand in marketing, and reviewing key differences between psychographic and demographic marketing.

His great insight into what we don't know about marketing is adopted from his bestseller - Seth Godin, This Is Marketing.

THIS IS Marketing book link: https://amzn.to/2AXqbBk
Click here to get a free audiobook copy of Seth Godin's NEW book: https://amzn.to/3z5gzQx

Here's everything you probably don't know about marketing from bestselling author, Seth Godin. His new book, This IS Marketing is probably the first and last book you'll ever need to buy on marketing. Hope you enjoy this Behind the Brand look with Seth.

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Join my Group: https://www..com/BryanElliott and get exclusive access to Behind the Brand full-length video episodes. These are VOD style videos you can watch and re-watch anytime...anywhere -- while in your jammies if you wish. This is much better than having to get all dressed up...paying $2,500 plus flights and hotel for an expensive seminar ticket to learn from someone amazing, at some event run by strangers, that costs a fortune. Instead you can enjoy these masterclass-style videos in privacy on your own for about the cost of a cup of coffee.

You deserve better than Shein.

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There are countless articles and videos breaking down the abysmal labor practices, horrifying environmental toll, and overall mountain of waste produced by the fast fashion industry. Activists and even just large swaths of the general public have been raising the alarm about this for well over a decade, but it hasn’t stopped the rise of some of the worst offenders in the industry. For example, the ultra-fast fashion brand Shein has skyrocketed in value over the past five years largely due to their marketing success on TikTok. A lot of us know that fast fashion is bad, but the only way companies like Shein still thrive is if we convince ourselves otherwise and hit “add to cart” anyway. So why do we do it?

The answer is that e-commerce has completely warped our view of what items should cost and how long they should last (this includes and extends to our obsession with Amazon and two-day shipping). We’re moving through trends at an unprecedented pace and it’s doomed to get worse if we don’t adjust our buying habits and learn to slow down. Consumers are being manipulated, but we can do better.

Watch the video above to learn more, and don’t forget to check out the Vox article by Izzie Ramirez: https://www.vox.com/even-bette....r/2023/11/14/2395567

You can also watch the sister video to this one from last year on why everything is worse now:
https://youtu.be/DHXBacEH0qo?si=wft1yGpeqbdcv1Vq

Help keep Vox free for everybody: http://www.vox.com/give-now

Sources and further reading:

Related Vox articles:
https://www.vox.com/the-goods/....2020/2/3/21080364/fa
https://www.vox.com/the-goods/....2021/7/19/22535050/g
https://www.vox.com/even-bette....r/2023/11/14/2395567
https://www.vox.com/the-goods/....23529587/consumer-go
https://www.vox.com/2019/9/12/....20860620/fast-fashio
https://www.vox.com/the-goods/....2020/1/27/21080107/f

Fashion transparency index: https://www.fashionrevolution.....org/about/transparen
The state of fashion: https://cdn.businessoffashion.....com/reports/The_Stat
More on the psychology of fast fashion: https://www.thesustainablefash....ionforum.com/pages/t

More on the environmental toll:
https://earth.org/fast-fashion....s-detrimental-effect
https://psci.princeton.edu/tip....s/2020/7/20/the-impa
https://www.unep.org/news-and-....stories/story/enviro
https://www.biologicaldiversit....y.org/programs/popul

You can find Cora’s book and blog here: https://www.thelingerieaddict.....com/in-intimate-deta

Video tags:
Fast fashion, fashion, waste, environment, shein, temu, h&m, zara, asos, tiktok, trends, trend cycles, consumers, consumerism, buying, clothing, pollution, runway, labor practices, unethical, hauls, shein haul, gen z, human rights, consumer goods, quality, brands, transparency, misinformation, uniqlo, trendy, cheap, inexpensive, true cost, cost, price, social media, e-commerce, greenwashing, even better, advice, service

A comprehensive plan—with goals, initiatives, and budgets–is comforting. But starting with a plan is a terrible way to make strategy. Roger Martin, former dean of the Rotman School of Management at the University of Toronto and one of the world’s leading thinkers on strategy, says developing strategy means going outside an organization’s comfort zone and escaping the common traps of strategic planning.00:00 Most strategic planning has nothing to do with strategy.01:00 So what is a strategy?02:08 Why do leaders so often focus on planning?04:05 Let's see a real-world example of strategy beating planning.06:33 How do I avoid the "planning trap"? For more from Roger Martin on this topic, read, "A New Way to Think: Your Guide to Superior Management Effectiveness": https://www.amazon.com/New-Way....-Think-Management-Ef Harvard Business Review:https://hbr.org/https://www.li....nkedin.com/company/h up for Newsletters: https://hbr.org/email-newslett....ers#HarvardBusinessR #strategy #rogermartincopyright © 2022 Harvard Business School Publishing. All rights reserved.#strategicplanning #planning #business #explainer #success #howto

Herein we have compiled some of the most interesting psychological facts that will blow your mind! Human psychology explores the mind and behavior, and while there’s still a lot that we don’t know, there are some fascinating and surprising study findings about the secrets of the mind.

This video provides insightful explanations to why yawns are contagious, why food tastes better when someone else makes it, why we unintentionally believe what we want to believe, and so much more!

These psychology facts will explain or confirm some of the things you observe in yourself and others!


OTHER VIDEOS TO WATCH:

7 Subconscious Mistakes Your Brain Makes Every Day:
https://www.youtube.com/watch?v=1tEBf_qMrMM

17 Interesting Facts About Love:
https://www.youtube.com/watch?v=FrZxarhJX5E

15 Amazing Facts About The Human Body:
https://www.youtube.com/watch?v=FxBlYh7Sg-E


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How to lead a happier, healthier and longer life. Check out our sponsor: https://betterhelp.com/veritasium to get matched with a professional therapist who will listen and help.

▀▀▀
A huge thanks to Prof. Robert Waldinger for all his help with this video.

To learn more about what makes for a good life, visit: https://the-good-life-book.com/ and https://www.youtube.com/watch?v=8KkKuTCFvzI&pp=ygUJd2FsZGluZ2Vy

A special thanks to Prof. Julianne Holt-Lunstad for her expert advice on the importance of social connections and the detrimental effects of loneliness and social isolation.

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Additional Videos:
Family Reacts to Winning CA$1 Million Lotto, NowThisNews via YouTube - https://ve42.co/CA1Lottery

Woman claims to be $1 billion Powerball winner, KTLA 5 via YouTube - https://ve42.co/1BilLottery

Old Lottery Winner Meets Young Lottery Winner | The Gap, LADbible TV via YouTube - https://ve42.co/LADBibleLottery

Why eyewitnesses get it wrong - Scott Fraser, TED-Ed via Youtube - https://ve42.co/TEDFraser

Surgeon General discusses health risks of loneliness and steps to help connect with others, PBS NewsHour via YouTube - https://ve42.co/PBS-SG

▀▀▀
References:
Waldinger, R., & Schulz, M. (2023). The Good Life: Lessons from the World's Longest Scientific Study of Happiness. Simon and Schuster.

Lindqvist et al. (2020). Long-run effects of lottery wealth on psychological well-being. The Review of Economic Studies. - https://ve42.co/Lindqvist2020

Wen et al. (2011). Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study. The lancet. - https://ve42.co/Wen2011

Nocon et al. (2008). Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis. European Journal of Preventive Cardiology. - https://ve42.co/Nocon2008

Blondell et al. (2014). Does physical activity prevent cognitive decline and dementia?: A systematic review and meta-analysis of longitudinal studies. BMC public health. - https://ve42.co/Blondell2014

Office of the Surgeon General. (2023). Our Epidemic of Loneliness and Isolation: The US Surgeon General’s Advisory on the Healing Effects of Social Connection and Community. - https://ve42.co/LonelinessEpidemic

Holt-Lunstad et al. (2010). Social relationships and mortality risk: a meta-analytic review. PLoS medicine. - https://ve42.co/Holt-Lunstad2010

Valtorta et al. (2016). Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies. Heart. -
https://ve42.co/Valtorta2016

Shovestul et al. (2020). Risk factors for loneliness: The high relative importance of age versus other factors. PloS one. - https://ve42.co/Shovestul2020

Donovan et al. (2017). Loneliness, depression and cognitive function in older US adults. International journal of geriatric psychiatry. - https://ve42.co/Donovan2017

Lara et al. (2019). Does loneliness contribute to mild cognitive impairment and dementia? A systematic review and meta-analysis of longitudinal studies. Ageing research reviews. - https://ve42.co/Lara2019

Holt-Lunstad et al. (2015). Loneliness and social isolation as risk factors for mortality: a meta-analytic review. Perspectives on psychological science. - https://ve42.co/Holt-Lunstad2015

McIntyre et al. (2015). Compulsive Internet use and relations between social connectedness, and introversion. Computers in Human Behavior. - https://ve42.co/McIntyre2015

Kahneman & Deaton. (2010). High income improves evaluation of life but not emotional well-being. Proceedings of the national academy of sciences. - https://ve42.co/Kahneman2010

Killingsworth. (2021). Experienced well-being rises with income, even above $75,000 per year. Proceedings of the National Academy of Sciences. - https://ve42.co/Killingsworth2021

Killingsworth et al. (2023). Income and emotional well-being: A conflict resolved. Proceedings of the National Academy of Sciences. - https://ve42.co/Killingsworth2023

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What does Psychology mean? Where does it come from? Hank gives you a 10-minute intro to one of the more tricky sciences and talks about some of the big names in the development of the field. Welcome to Crash Course Psychology!!!

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Want to support my work? You can sign up for a paid subscription to my newsletter and YouTube channel here - https://www.distilled.earth/In this video we cover enhanced geothermal and the role it could play in decarbonizing the world's electric grid.Recently there have been a series of breakthroughs in enhanced geothermal systems, an advanced method of generating electricity from the Earth’s heat. If these developments continue, geothermal could generate between 10 and 20 percent of the country’s electricity in the coming decades, according to recent studies from the Department of Energy and Princeton.Enhanced geothermal could also solve one of clean energy’s biggest problems: intermittency. Unlike solar and wind, geothermal power plants can operate at all hours of the day, no matter the weather or time of year. In this story, I’ll cover the past, present, and future of enhanced geothermal and look at what needs to happen in order for the technology to play a large role in decarbonizing America’s power sector.All sources can be found in my article on the same topic here: https://www.distilled.earth/p/....the-new-clean-energy #technology #sustainability #geothermal #energy

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In the 1600s, the Dutch East India Company employed hundreds of ships to trade goods around the globe. In order to fund their voyages, the company turned to private citizens to invest money to support trips in exchange for a share of the profits. In doing so, they unknowingly invented the world’s first stock market. So how do companies and investors use the market today? Oliver Elfenbaum explains.

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Take a thorough look inside a modern jet passenger aircraft. Electronics, hydraulics, flight control surfaces, fuel system, water and waste, lighting, and more!

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Michel Foucault was a philosophical historian who questioned many of our assumptions about how much better the world is today compared with the past. When he looked at the treatment of the mad, at the medical profession and at sexuality, he didn't see the progress that's routinely assumed.

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“Michel Foucault (1926-1984) was a French 20th-century philosopher and historian who spent his career forensically critiquing the power of the modern bourgeois capitalist state, including its police, law courts, prisons, doctors and psychiatrists. His goal was to work out nothing less than how power worked and then to change it in the direction of a Marxist-anarchist utopia. Though he spent most of his life in libraries and seminar rooms, he was a committedly revolutionary figure, who met with enormous popularity in elite Parisian intellectual circles (Jean Paul Sartre admired him deeply) and still maintains a wide following among young people studying at university in the prosperous corners of the world…”

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